We use the methods of the qualitative theory of differential equations and statistical approaches to model and analyze a wide range of physical and biological systems.
Our main research interests are the reconstruction of dynamical systems from data of different origins.
This includes building models from the "first principles" like naturalistic models of neurons and neural networks or (bio)chemical kinetics as well as the data assimilation from noisy time series and other inverse problems.
Our current research projects are concerned with the modeling the interactions between respiratory and cardio-vascular neural circuits in brainstem, as well as spinal circuits that control quadrupedal and bipedal locomotion.
These studies involve multivariate time-series analysis of nerve and unit activities, data assimilation approaches, numerical modeling and simulation,
asymptotic methods of dynamical systems reduction, qualitative analysis of dynamical systems, etc.
Our research projects require solid background in mathematics, physics and computational neuroscience, strong programming skills and involve processing and analysis of experimental data, computer modeling of the neurons, neural networks and large-scale neural systems,
and analysis of the models using dynamical system theory.
As a postdoctoral fellow in Rybak's group at Drexel University College of Medicine, I intensively studied neurophysiology of respiration and locomotion
and significantly contributed to the development of several novel computational models of the brainstem respiratory network.
These models constitute a basis for their further extension. In addition, we are developping novel approaches to parallel computing for the simulation of large, multi-population neural models and,
using this approaches, we are implementing our multi-scale respiratory models in the heterogeneous multiprocessor clusters and GPU systems.
| 11/2022 | Neuroscience 2022, San Diego, CA
On the role of sensory feedback and central neuronal interactions in locomotor gait and balance control in quadrupeds
Comparative investigation of control mechanisms of locomotion and turning using a simulated quadrupedal robot
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| 08/2022 | Alzheimer's Association International Conference, San Diego, CA
Bridging the gap between cellular amyloid metabolism and Alzheimer\92s disease clinical data
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| 07/2021 | Alzheimer's Association International Conference, Denver, CO
Lysosomal permeabilization as a mechanism of amyloid degradation toxicity in Alzheimer's disease
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| 06/2021 | Virtual SMB 2021 Annual Meeting, Riverside, CA
Invited talk: Control of steering in quadrupedal locomotion
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| 10/2020 | 2020 Virtual Workshop on Motor Control, Cleveland, OH
Invited talk: Complicated relationships between respiration, heart beat and blood pressure
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| 10/2020 | 13th Annual Society for Neuroscience Satellite Symposium on Motor Systems, Washington, DC
Invited talk: Neural Mechanisms of Cardio-Respiratory Interactions
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| 10/2019 | Neuroscience 2019, Chicago, IL
Cats stepping on a split belt treadmill reveal a functional organization of commissural interactions within the spinal locomotor circuits
Expiratory inhibition is a mechanism for adaptive control of breathing
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| 07/2019 | Computational Neuroscience 2019, Barcelona, Spain
Sympathetic and parasympathetic mechanisms of enhanced respiratory modulation of blood pressure and heart rate during slow deep breathing
Pontine mechanisms of abnormal breathing
Interlimb coordination during split-belt locomotion: a modeling study
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| 05/2019 | SIAM Conference on Applications of Dynamical Systems 2019, Snowbird, UT
Cardio-Respiratory Interactions: Neural Mechanisms
Invited talk: Left-right coordination in the mammalian locomotor CPG
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| 11/2018 | Neuroscience 2018, San Diego, CA
Brainstem mechanisms of cardio-ventilatory coupling
The role of striatal tonically active neurons in reinforcement learning: a modeling study
Sympathetic overactivity after chronic intermittent hypoxia has different mechanisms in male and female rats
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| 07/2018 | Computational Neuroscience 2018, Seattle, WA
Functional role of 5-HT1A receptors in serotonergic modulation of active exhalation
Brainstem mechanisms of cardio-respiratory coupling
Cholinergic modulation of reinforcement learning in the striatum
Invited talk: TRP channels and intracellular calcium dynamics in the pre-B\F6tzinger complex
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| 06/2018 | 2018 CRCNS PI Meeting, University of California, Berkeley, CA
Serotonergic modulation of breathing: functional role of 5-HT1A receptors
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| 05/2018 | Society for the Neural Control of Movement 28th Annual Meeting, Santa Fe, New Mexico
Interactions of balance control and locomotion in cats walking on a split-belt
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| 03/2018 | 95th Annual meeting of the Physiological Society of Japan, Takamatsu, Kagawa, Japan
Reconstructed postsynaptic excitatory and inhibitory conductance profiles of respiratory interneurons in rat brainstem in situ reveal network organization of respiratory CPG
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| 11/2017 | Neuroscience 2017, Washington, DC
Frontal plane dynamics of quadrupedal locomotion on a split-belt treadmill
Homeostatic motor adaptation: cerebellum's failure emboldens basal ganglia
Inhibitory interactions in the brainstem respiratory circuits: Insights from optogenetic studies and computational modeling
Local glutamatergic transmission in the RTN/pFRG is critical for active expiration and sympathetic overactivity during hypercapnia |
| 09/2017 | XIV Oxford Conference on Modelling and Control of Breathing, Oxford, United Kingdom
Invited talk: TRP channels and intracellular calcium dynamics in the pre-B\F6tzinger complex
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| 07/2017 | Computational Neuroscience 2017, Antwerp, Belgium
The interplay between basal ganglia and cerebellum in motor adaptation
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| 06/2017 | CRCNS PI Meeting 2017, Brown University, Providence, RI
Optogenetic probing of glycinergic neuron function in brainstem respiratory circuits
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| 05/2017 | SIAM Conference on Applications of Dynamical Systems, Snowbird, UT
Glycinergic neurons in the pre-Bötzinger complex are crucial for eupnea: an optogenetic study |
| 04/2017 | Georgia Tech School of Applied Physiology Research Seminar, Atlanta, GA
Invited talk: The interplay between cerebellum and basal ganglia in motor adaptation |
| 12/2016 | Workshop on Computational Modeling of Respiratory Central Pattern Generators, University of Pittsburgh, PA
Invited talk: Kolliker-Fuse Orchestrates Timing Of Abdominal Nerve Bursting |
| 11/2016 | Neuroscience 2016, San Diego, CA
Kolliker Fuse orchestrates timing of abdominal nerve bursting
Glycinergic neurons in the pre-Botzinger complex are crucial for eupnea: an optogenetic study
Optogenetic stimulation of pre-Botzinger complex and Botzinger complex inhibitory neurons reveals a major role of inhibition in respiratory central pattern generation
Reward based motor adaptation mediated by basal ganglia |
| 10/2016 | CRCNS Conference 2016, Paris, France
Kolliker-Fuse Orchestrates Timing Of Abdominal Nerve Bursting |
| 07/2016 | Computational Neuroscience 2016, Jeju, South Korea
Action Selection and Reinforcement Learning in Basal Ganglia during Reaching Movements
Invited talk: Coupled oscillations in the brainstem respiratory circuits and neurogenic hypertension |
